Identification of Cross-Reactive Norovirus CD4 + T Cell Epitopes
نویسندگان
چکیده
منابع مشابه
Identification of Cross - reactive 1 Norovirus CD 4 + T Cell Epitopes 2 3 Anna
6 Department of Microbiology and Immunology, School of Medicine 1 , 7 Department of Epidemiology, School of Public Health 2 , University of 8 North Carolina at Chapel Hill 9 10 11 Running Title: Norovirus T cell epitopes 12 13 Corresponding Author: 14 Ralph S. Baric, PhD 15 Professor 16 3304 Hooker Research Center 17 Department of Epidemiology 18 School of Public Health 19 University of North C...
متن کاملCross-presentation of Listeria monocytogenes-derived CD4 T cell epitopes.
Listeriolysin O (LLO) mediates the evasion of Listeria monocytogenes from the phagolysosome into the cytoplasm of the host cell. The recognition of infected cells by CD4 T cells is thought to be limited by the evasion of bacteria from the phagolysosome and also by the direct LLO-mediated inhibition of CD4 T cell activation. To analyze the influence of these immunoevasive mechanisms on the antil...
متن کاملOriginal Article: Highly conserved cross‐reactive CD4+ T‐cell HA‐epitopes of seasonal and the 2009 pandemic influenza viruses
BACKGROUND The relatively mild nature of the 2009 influenza pandemic (nH1N1) highlights the overriding importance of pre-existing immune memory. The absence of cross-reactive antibodies to nH1N1 in most individuals suggests that such attenuation may be attributed to pre-existing cellular immune responses to epitopes shared between nH1N1 virus and previously circulating strains of inter-pandemic...
متن کاملCross-conservation of T-cell epitopes
A novel avian-origin H7N9 influenza strain emerged in China in April 2013. Since its re-emergence in October-November 2013, the number of reported cases has accelerated; more than 220 laboratory-confirmed cases and 112 deaths (case fatality rate of 20-30%) have been reported. The resurgence of H7N9 has re-emphasized the importance of making faster and more effective influenza vaccines than thos...
متن کاملIdentification of Genogroup I and Genogroup II broadly reactive epitopes on the norovirus capsid.
Norwalk virus, a member of the family Caliciviridae, is an important cause of acute epidemic nonbacterial gastroenteritis. Norwalk and related viruses are classified in a separate genus of Caliciviridae called Norovirus, which is comprised of at least three genogroups based on sequence differences. Many of the currently available immunologic reagents used to study these viruses are type specifi...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2010
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.00727-10